Biography:

Abigail Basson has completed her PhD from the University of the Western Cape, South Africa, where she is presently a Lecturer of Nutrigenomics and Medical Nutrition Therapy. She received her MSc degree in Nutrition Science from New York University (USA) and also holds a Postgraduate qualifi cation in Nutrigenomics from the University of Arizona. She has authored several publications in reputed journals and is serving as an Editorial Board Member of repute.

Abstract:

Signifi cant diff erences in CD susceptibility genotype have been identifi ed between the racial groups in South Africa; however there is no recent data for such groups describing the disease phenotype or clinical features. We performed a cross sectional examination of all consecutive Crohn’s disease (CD) patients seen at 2 large infl ammatory bowel disease (IBD) referral centers in the Western Cape, South Africa between September 2011- January 2013. Numerous demographic and clinical variables at diagnosis and date of study enrolment were identifi ed via; investigator-administered questionnaire; clinical examination; and patient case notes. Using predefi ned defi nitions, disease behaviour was stratifi ed as ‘complicated’ or ‘uncomplicated’. All statistical analysis included only White and Coloured subjects, due to the small number of Black subjects. Over an approximate 17 month period we identifi ed; 35 (18%) White; 152 (78%); Coloured; 7(4%) Black subjects. On multiple logistic regression analysis there was no signifi cant diff erence between Coloured and White subjects with regard to CD location, or CD behaviour at diagnosis. However, signifi cantly more Coloured subjects had developed ‘complicated’ CD (60% vs. 9%) during the disease course compared to Whites. In addition, all Black subjects developed ‘complicated’ CD within 3 years aft er diagnosis. Th ere was no signifi cant inter-racial diff erence in terms of extraintestinal manifestations or medical management. A low proportion of IBD family history was observed among the non-White subjects. Compared to earlier reports, our data suggests a rising CD prevalence among the non-White populations. Th ese observed trends lend support to both diff erent susceptibility genes and variable environmental interactions between racial groups.

Biography:

Joshua Ko disciplines include pharmacology, toxicology, chemotherapy and gastroenterology. My current research interest and strength focus on the study of the carcinogenesis and pharmacotherapy of gastrointestinal cancers (particularly colon) by using active herbal medicinal compounds, and also on the identifi cation of key molecular drug targets. I have recently explored the potential anti-nociceptive and anti-infl ammatory actions of TCM formulations and single herbal drugs in the treatment of cancer pain and infl ammation pain. I employ different cell and molecular biology methods, animal models of cancer and pain, with increasing works using proteomics and metabolomics approaches in our current studies. The new ventures in the coming years include research works on micro-RNA and tumor-targeting peptides delivery system.

Abstract:

The dried root of Astragalusmembranaceus (Radix Astragali) has a long history of medicinal use in Traditional Chinese Medicine as an immunomodulating agent to ameliorate the side eff ects of cytotoxic antineoplastic drugs. In recent years, we have demonstrated that total Astragalussaponins (AST) caused signifi cant growth inhibition and pro-apoptotic eff ects in human colon adenocarcinoma cells and tumor xenograft , which synergistically worked with conventional chemotherapeutic drug combowhile alleviatingthe associated drug-induced toxicity. Its mechanism of action involved phase-specifi c cell cycle arrest and exhibited anticarcinogenic activity in 8 diff erent human cancer cell lines, confi rming its universal chemotherapeutic property. By using customized cDNA array, we have revealed that AST increased the gene expression of proangiogenic factors and downregulated the expression of proangiogenic molecules. Besides, genes that are relevant to metastasis and invasion including matrix metallopeptidases and the metastasis associated genes mta1 and Twist were also downregulated. Contribution of AST to the modulation of angiogenesis, tumor invasiveness and metastasis was further confi rmed. Th e anti-metastatic potential of AST could be demonstrated by employing a modifi ed liver metastasis model. We have identifi ed NSAID-activated gene (NAG-1) as a molecular target of AST, which could be correlated with modulation of the upstream PI3K-AST signaling pathway. Other than colorectal cancer cells, AST has also exhibited promising anti-carcinogenic eff ects in hepatocarcinoma cells by down-regulating expression of the liver tumor marker α-fetoprotein, as well as promoting pro-apoptotic activity through modulation of an ERK-independent NF-кB signaling pathway. Glucose-regulated proteins (GRP) are induced in the cancer microenvironment to promote tumor survival, metastasis and drug resistance.Our fi ndings exemplify that calpains, in particular calpain II, played a permissive role in the modulation of GRP78 and consequent regulation of ER stress-induced apoptosis brought forth by AST.Data obtained from these studies could facilitate future establishment of AST as an eff ective target-specifi c chemotherapeutic and adjuvant agent in treating human colorectal and liver cancers, with unique molecular targets such as NAG-1 and calpain.

Biography:

Christos Tzormpatzakis Graduated from the 5th general Lyceum of Ilion-Athens in the year 1996. The same year was enrolled in the 1st year of Medical faculty, of P. J. Safarik University in Kosice- Slovakia. Graduated on 2002. Occupation license to practice medicine in European Union since 23-7-2004 and specialty of Pediatrics since 5-12-2012. Attended medical training in Greek Air Force school on 2007. Master of Science in medical statistics at Athens University of Economics, on 2012. PhD thesis on “Correlation between birth weight and renal function in children born with vesicoureteral refl ux”, on 2014. Teacher/Instructor in State Institute of Occupational Training, teaching general Dermatology, Anatomy, Physiology, First Aid, Pediatrics and Neonatology, since 2008

Abstract:

Introduction: It’s widely approved that children with a history of refl ux are of greater risk for development of renal scarring and impaired kidney function later in life, which may be expressed by development of chronic diseases such as hypertension in adulthood. Although during the past two decades, researchers have tried to unravel the hypothesis that there is a relation between low birth weight (LBW) and kidney function in adolescence, the published data regarding the eff ect of birth weight on kidney function in children born with vesicourinary refl ux is still insuffi cient to prove or reject any relationship in this special category of children. Purpose: Is to examine whether this association exists and onto which parameters, in a cross-sectional study. Materials and Methods: Sixty-one children (20 boys, 41 girls) born the years from 1985 to 1989, in diff erent parts of Greece, with vesicoureteral refl ux which was diagnosed either due to progenital testing, or urinary tract infection (UTI) such as cystitis.Detailed personal and family history was taken, Also anthropometric measurements of each adolescent such as weight and height, calculation of glomerular filtration rate (GFR), and fractional excretion of sodium (FeNa), measurement of albumin, a1 and b2 globulin and microalbumin of the urine, creatinine clearance (CrCl) from a 24-hour-urine collection, complete lipid profi le and cystatin. Blood pressure measurement (BPM)and grade of vesicoureteral refl ux and DMSA are taken into account. Volume, width, length and thickness of kidneys was calculated with the use of ultrasound diagnostic machine. Results: Results obtained, prove a positive relation of birth weight (p=0.01), on blood pressure in adolescence, in children diagnosed with any degree of vesicourinary refl ux. Renal function seems to be intact, respectively the cause of vesicoureteral refl ux, the volume of kidneys in adolescence (p=0.386 and p=0.483 respectively for right and left kidney) and the values of GFR (p=0.105), CrCl (p=0.213) and cystatin(0.055). Conclusions: Our results shows that although there is a positive association between blood pressure in adolescence and birth weight, in children born with vesicourinary reflux, no deterioration of renal function was found. Th e reason is probably that higher blood pressure maybe due to other confounding factors- diffi cult to measure such as socioeconomic status.

Biography:

Jose Luis Mosso Vazquez is a Researcher at the Universidad Panamericana and Clinical-surgical practitioner in Public Health Institutions in Mexico City. He developed the fi rst robot (Tonatiuh) to hold laparoscope as assistance in Endoscopic surgery in Mexico in 1996. He introduce Cybertherapy in 15 differents areas in Medicine with highlights in ambulatory surgery reducing pain and anxiety considerably. The recent contribution is using tablets and smartphones as Surgical simulators for endoscopic surgery training in 304 undergraduate students since 2010 until today, At the Universidad Panamericana. He perform Emergency Surgeries at the Regional Hospital number 25 of the IMSS (Instituto Mexicano del Seguro Social) since 2000 until today, performing surgical repairs on neck, thoracic, gastrointestinal and pelvic regions. He serves as Gastrointestinal Endoscopist since 1997 until today at the ISSSTE (Instituto de Seguridad y Servicios Sociales para los Trabajadores del Estado).

Abstract:

Objective: We present surgical experience with endoscopic trainers with smart phones, tablets and Wii game at the Faculty of Medicine at the Universidad Panamericana, Mexico City. Methodology: Two specific holders were designed and built to hold real laparoscopic tools. Results: 300 undergraduate students have used serious game trainers since 2010 and they performed the followings 4 surgical procedures: Laparoscopy, nefrectomy, splenectomy and appendectomy on animal model. Conclusions: Students developed hand-eye coordination and time reduced to make knots and sutures. We suggest serious game as complementary and useful tool for teaching introduction and for warm up for endoscopic surgery in the career of medicine for undergraduate students. Our program of surgery included endoscopic surgery in the second and fourth year of the career and conventional endoscopic tools were used as complement at the end of each course of one month.

Biography:

Azza El-Medany has completed her PhD at the age of 32 years from Alexandria University and Postdoctoral studies from Alexandria University College of Medicine. She is Prof. of Pharmacology and Vice Head of Department of Pharmacology, College of Medicine, KSU. She published more than 25 papers in the areas of GIT & toxicological researches, in reputed journals and is serving as a member of a number of Professional Bodies; was a speaker in several international conferences, the last ones in Singapore & Japan 2013. She is a recipient of awards for scientifi c research & teaching.

Abstract:

Residential and agricultural pesticide use is widespread in the world. Th eir indiscriminative use with their ability to interact with biological systems, constitute a health hazard. 40 adult male rats were classifi ed into three groups; control received corn oil (10mg/kg/day). Diazinon received diazinon (10mg/kg/day). Mesna group (15 rats) received mesna 180mg/kg once a week 15 min before administration of diazinons. At the end of the experiment (2 months), animals were anesthetized , blood samples were taken for glucose and insulin assays & pancreas were removed and divided into 3 portions; for histopathological, ultrastructural and biochemical studies. A signifi cant increase in the levels of malondialdehyde, TNF-α, myeloperoxidase activity, IL-1β , serum glucose levels in the toxicated group were observed , while a signifi cant reduction was noticed in GSH and in serum insulin levels. Aft er treatment with mesna a signifi cant reduction was observed in the previously mentioned parameters except that there was a signifi cant rise in GSH & in insulin levels. Histopathological and ultrastructural studies showed destruction in pancreatic tissues and the β cells were the most aff ected cells. Th is study shows the role of antioxidant drugs in ameliorating the toxicity that is considered as a complementary treatment of pesticide toxicity.

Biography:

Vikas Leelavati Balasaheb Jadhav has completed Postgraduation in Radiology in 1994. He has a 19 Years of experience in the fi eld of Gastro-Intestinal Tract Ultrasound & Diagnostic as well Therapeutic Interventional Sonography. He has four Indian Patents & an International Patent published on his name in the fi eld of Gastro-Intestinal Tract Sonography & the Radiology, since 2008. He has delivered many Guest Lectures in Indian as well International Conferences in nearly 20 countries as an Invited Guest Faculty, since 2000. He is a Consultant Radiologist & the Specialist in Unconventional Gastro-Intestinal Tract Ultrasound & Diagnostic as well Therapeutic Interventional Sonologist in Pune, India

Abstract:

Transabdominal Sonography of the Stomach & Duodenum can reveal following diseases. Gastritis & Duodenitis. Acid Gastritis. An Ulcer, whether it is superfi cial, deep with risk of impending perforation, Perforated, Sealed perforation, Chronic Ulcer & Post-Healing fi brosis & stricture. Polyps & Diverticulum. Benign intra-mural tumours. Intra-mural haematoma. Duodenal outlet obstruction due to Annular Pancreas. Gastro-Duodenal Ascariasis. Pancreatic or Biliary Stents. Foreign Body. Necrotizing Gastro- Duodenitis. Tuberculosis. Lesions of Ampulla of Vater like prolapsed, benign & infi ltrating mass lesions. Neoplastic lesion is usually a segment involvement, & shows irregularly thickened, hypoechoic & aperistaltic wall with loss of normal layering pattern. It is usually a solitary stricture & has eccentric irregular luminal narrowing. It shows loss of normal Gut Signature. Enlargement of the involved segment seen. Shouldering eff ect at the ends of stricture is most common feature. Enlarged lymphnodes around may be seen. Primary arising from wall itself & secondary are invasion from peri-Ampullary malignancy or distant metastasis. All these cases are compared & proved with gold standards like surgery & endoscopy. Some extra eff orts taken during all routine or emergent ultrasonography examinations can be an eff ective non-invasive method to diagnose primarily hitherto unsuspected benign & malignant Gastro-Intestinal Tract lesions, so should be the investigation of choice.

Biography:

Jose Luis Mosso Vazquez researcher at the Universidad Panamericana and Clinical-surgical practitioner in Public Health Institutions in Mexico City. He developed the fi rst robot (Tonatiuh) to hold laparoscope as assistance in Endoscopic surgery in Mexico in 1996. He introduce Cybertherapy in 15 differents areas in Medicine with highlights in ambulatory surgery reducing pain and anxiety considerably. The recent contribution is using tablets and smartphones as Surgical simulators for endoscopic surgery training in 304 undergraduate students since 2010 until today, At the Universidad Panamericana. He perform Emergency Surgeries at the Regional Hospital number 25 of the IMSS (Instituto Mexicano del Seguro Social) since 2000 until today, performing surgical repairs on neck, thoracic, gastrointestinal and pelvic regions. He serves as Gastrointestinal Endoscopist since 1997 until today at the ISSSTE (Instituto de Seguridad y Servicios Sociales para los Trabajadores del Estado).

Abstract:

Objective: We present surgical experience with endoscopic trainers with smart phones, tablets and Wii game at the Faculty of Medicine at the Universidad Panamericana, Mexico City. Methodology: Two specifi c holders were designed and built to hold real laparoscopic tools. Results: 300 undergraduate students have used serious game trainers since 2010 and they performed the followings 4 surgical procedures: Laparoscopy, nefrectomy, splenectomy and appendectomy on animal model. Conclusions: Students developed hand-eye coordination and time reduced to make knots and sutures. We suggest serious game as complementary and useful tool for teaching introduction and for warm up for endoscopic surgery in the career of medicine for undergraduate students. Our program of surgery included endoscopic surgery in the second and fourth year of the career and conventional endoscopic tools were used as complement at the end of each course of one month.

Biography:

ahmed e. lasheen has about 20 international papers, prof. Of general and lap. Surgery , faculty of medicin, zagazig university, egypt. Email; lasheenahmed@yahoo.com and work now saudi arabi, riyadh

Abstract:

Background: Acute appendicitis is the most frequent abdominal disease and requires urgent surgery. At thepresent time, laparoscopic appendectomy is a well-acceptedemergency procedure at most centers. In this study, we used a new spiral needle to facilitate the procedure, making it easy, minimally invasive, and cost eff ective. Methods: Th e study included 70 patients of both sexes with acute appendicitis that was treated by laparoscopic appendectomy using a new spiral needle. Th ese cases were treated at the General Surgery Department, Zagazig University, Egypt, from May 2012 to August 2013. In the procedure we used only two ports (a 10-mm port directly below the umbilicus for the camera and a 5-mm port at the left iliac fossa at the midclavicular line). Th e new spiralneedle was used to hold the appendix during the procedureand was inserted into the right iliac fossa depending on thesite of the appendix. Results: Th e mean age of the patients was 27.3 years,mean operative time was 40 min, and mean hospital staywas 1.3 days. Ten patients (14 %) had minimal bleeding atthe site of needle passage into the meso appendix. Woundinfection at the site of umbilical port occurred in fourpatients (5.7 %) postoperatively. Conclusion:Laparoscopic appendectomy using our newspiral needle is easy, minimally invasive, and costeff ective.

Biography:

Fisseha Shiferie completed his master’s degree at the age of 26 years from Addis Ababa University and studying for another master’s degree in France at the France School of Public Health.

Abstract:

Diarrhea is a common gastrointestinal disorder characterized by an increase in stool frequency and a change in stool consistency. Inspite of the availability of many drugs as antidiarrheal agents, the search for a drug with aff ordable cost and better effi cacy is essential to overcome diarrheal problems. Th e root extract of Echinopskebericho, is used by traditional practitioners for the treatment of diarrhea. However, the scientifi c basis for this usage has not been yet established. Th e purpose of the present study was to evaluate the antidiarrheal and spasmolytic activities of the aqueous extract of the roots of E. kebericho in rodents and isolated guinea-pig ileum preparations. In the castor oil induced intestinal transit test, E.kebericho produced a signifi cant (p < 0.01) dose dependent decrease in propulsion with peristaltic indexvalues of 45.05±3.3, 42.71±2.25 and 33.17±3.3%, respectively at doses of 100, 200 and 400 mg/kg compared with 63.43±7.3% for control. In the castor oil-induced diarrhea test, the mean defecation was reduced from 1.81±0.18 to 0.99 ± 0.21 compared with 2.59 ±0.81 for control. Th e extract (at doses stated above) signifi cantly decreased the volume of intestinal fl uid secretion induced by castor oil (2.31±0.1 to 2.01±0.2) in relation to 3.28±0.3 for control. When tested on a guineapig ileum, root extract of Echinopskebericho exhibited a dose dependent spasmolytic eff ect, 23.07 % being its highest inhibitory eff ect. Th e results obtained in this study give some scientifi c support to the use of Echinopskebericho as an antidiarrheal agent due to its inhibitory effects on the different diarrheal parameters used in this study.

Biography:

Abstract: