Gastroenterology

Biography

Biography: Christos Tzormpatzakis

Abstract

Introduction: It’s widely approved that children with a history of refl ux are of greater risk for development of renal scarring and impaired kidney function later in life, which may be expressed by development of chronic diseases such as hypertension in adulthood. Although during the past two decades, researchers have tried to unravel the hypothesis that there is a relation between low birth weight (LBW) and kidney function in adolescence, the published data regarding the eff ect of birth weight on kidney function in children born with vesicourinary refl ux is still insuffi cient to prove or reject any relationship in this special category of children. Purpose: Is to examine whether this association exists and onto which parameters, in a cross-sectional study. Materials and Methods: Sixty-one children (20 boys, 41 girls) born the years from 1985 to 1989, in diff erent parts of Greece, with vesicoureteral refl ux which was diagnosed either due to progenital testing, or urinary tract infection (UTI) such as cystitis.Detailed personal and family history was taken, Also anthropometric measurements of each adolescent such as weight and height, calculation of glomerular filtration rate (GFR), and fractional excretion of sodium (FeNa), measurement of albumin, a1 and b2 globulin and microalbumin of the urine, creatinine clearance (CrCl) from a 24-hour-urine collection, complete lipid profi le and cystatin. Blood pressure measurement (BPM)and grade of vesicoureteral refl ux and DMSA are taken into account. Volume, width, length and thickness of kidneys was calculated with the use of ultrasound diagnostic machine. Results: Results obtained, prove a positive relation of birth weight (p=0.01), on blood pressure in adolescence, in children diagnosed with any degree of vesicourinary refl ux. Renal function seems to be intact, respectively the cause of vesicoureteral refl ux, the volume of kidneys in adolescence (p=0.386 and p=0.483 respectively for right and left kidney) and the values of GFR (p=0.105), CrCl (p=0.213) and cystatin(0.055). Conclusions: Our results shows that although there is a positive association between blood pressure in adolescence and birth weight, in children born with vesicourinary reflux, no deterioration of renal function was found. Th e reason is probably that higher blood pressure maybe due to other confounding factors- diffi cult to measure such as socioeconomic status.