Gastroenterology

Biography

Biography: Ahmed Ellakany

Abstract

Eosinophilic esophagitis is a clinicopathologic disease characterized by upper intestinal symptoms and the fi nding of more than 15 or 20 eosinophils in the esophageal epithelium. Lack of awareness to EoE among some gastroenterologists made the disease under recognized. Patients with eosinophilic esophagitis should be referred to both an allergist and gastroenterologist for optimal management which may include dietary modifi cations, pharmacologic agents, ingested fl uticasone and its role in EOE will be discussed in this study. Th is study was conducted at faculty of medicine,Alexandria University, Internal Medicine Department. Th e study was conducted on twenty patients who were complaining from recurrent dysphagia and done upper GIT endoscopy and diagnosed histopathologically as EOE. Th e 20 patients was randomly assigned to receive either placebo (n=10) or swallowed fl uticasone (n=10). Treatment lasted for four weeks and follow up extended up to 8 months. Aft er 4 weeks treatment, clinical symptoms and histological changes were evaluated. Histologic improvement in the form of full histological remission was seen in seven patients in the fl uticasone group compared with one patient who achieved remission in the placebo group. In conclusion, the study highlights the problems of diagnosis and lack of awareness and understanding of the etiology and pathogenesis of the disease. Th e use of ingested fl uticasone showed improvement of symptoms and histological pattern.