Meet Inspiring Speakers and Experts at our 3000+ Global Conference Series Events with over 1000+ Conferences, 1000+ Symposiums
and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.

Explore and learn more about Conference Series : World's leading Event Organizer

Back

Mohammed Omer

Mohammed Omer

University of Sulaimani, Kurdistan

Title: Clinical and Biochemical Effects of Life Style Modification, Pentoxifylline or Vitamin E in Patients with NASH in Sulaimani-Kurdistan Region

Biography

Biography: Mohammed Omer

Abstract

Background: The burden of Non-Alcoholic Steatohepatitis (NASH) is growing and current pharmacologic treatments are limited by side effects and inconsistent efficacy. Pilot studies suggest that Pentoxifylline (PTX) and vitamin E can reduce degree and pattern of fatty liver, liver enzyme and inflammatory marker in patients with NASH.

Objectives: To evaluate the clinical, biochemical and ultrasonographic effects of life style modification (LSM), PTX, and vitamin E in patients with NASH, and to develop a pharmaceutical care plan for patients included in this study.

Methods: This is a double blind placebo control study. A total of 110 participants with NASH, diagnosed by ultrasonography (U.S) and raised aminotransferase level were included. Demographic data, anthropometric measures such as Body Mass Index(BMI), waist/hip ratio were taken, liver function test, lipid profile, blood glucose, and High sensitivity C - reactive protein (Hs-CRP). The patients were divided into three comparable groups in age, gender and BMI. All enrolled participants were treated by LSM but pharmacologically they were randomly divided into three groups, receiving Placebo, vitamin E or PTX for 6months.

Results: Out of 110 participants, only 90 participants (48 male, 42 female) completed this study. All the three groups showed decreased steatosis by U.S and significant reduction in aminotransferase levels, Hs-CRP, v profile, blood glucose, blood pressure and waist circumference compared to baseline. All changes were more significant among vitamin E and PTX than placebo group.

Conclusions: PTX or vitamin E with dietary modification and exercise led to significant improvement in hepatic steatosis, reduction in aminotransferase levels and improved inflammatory marker (Hs-CRP).

Keywords: NASH, Lifestyle, Pentoxifylline, Vitamin E, Pharmaceutical care, Sulaimani