Seyedeh Azra Shamsdin
Shiraz University of Medical Sciences, Iran
Title: Markers ERp57 and VEGF expression in Gastric Cancer Patients
Biography
Biography: Seyedeh Azra Shamsdin
Abstract
Introduction: Studies of gastric metaplasia and neoplasia in mouse models have informed us about the pathway to gastric carcinogenesis. VEGF and ERp57 were identified as markers for gastric metaplasia.
Aim: To investigate the expression of VEGF and ERp57 in gastric metaplasia and adenocarcinoma in humans.
Methods: 224 paraffin-embedded tissues from 112 patients with gastric cancer were stained for ERp57and VEGF by horseradish peroxidase immunohistochemical technique, in which VEGF or ERp57 quantification score is obtained.
Results: The level of VEGF expression was significantly higher in metaplasia and adenocarcinoma than that in normal gastric mucosa (p≤0.01).VEGF score revealed significant differences in differentiation degree, and histological type of the gastric carcinoma and depth of invasion (p≤0.05).ERp57 staining significantly increased in normal gastric mucosa, compared with that in cancer and metastases (p≤0.05).ERp57 expression correlated with greater depth of tumor and advanced stages (p≤0.01).
Conclusion: High VEGF expression and low ERp57 expression are correlated with the progression of gastric cancer. Therefore, VEGF and ERp57 are prognostic markers for such patients.