Thi-Ut Nguyen is a Pediatrician. She has been working as Gastroenterologist in Gastroenterology Department of the National Pediatric Hospital. She has conducted several studies on Helicobacter pylori antibiotics resistance of gastritis and peptic ulcer among children
Statement of the Problem: Helicobacter pylori (H. pylori) antibiotics resistance is the major cause of failure in eradicating H. pylori. Recent studies have showed that the virulence genes associated with H. pylori antibiotics resistance have been isolated from adult peptic ulcer patients. To date, however, there is still lack of evidene about this in Vietnamese pediatric children. The objective of this study is to evaluate the association between H. pylori antibiotics resistance and the presence of cagA and vacA genes in pediatric patients. Methodology & Theoretical Orientation: 150 samples of H. pylori isolated from 150 infected pediatric patients whose antimicrobial susceptibility showed a resistance to at least 1 of 3 antibiotics: amoxicillin, clarithromycin and metronidazole. The cagA and vacA genes were detected by using multiplex PCR (Polymerase Chain Reaction), between January, 2012 through September, 2013 in National Hospital of Pediatrics, Hanoi, Vietnam.Findings: The result showed that the cagA gene was detected in 34% H. pylori strains. The rate of vacAs1, vacAs2, vacAm1, vacAm2, vacAs1/m1, vacAs1/m2 and vacAs2/m2 were 39.3%, 14.7%, 37.3%, 23.3%, 16.7%, 11.3% and 6.6% respectiverly. 8% strains harboured three virulence genes cagA, vacAm1 and vacAs1.Conclusion & Significance: The prevalence of cagA and the vacA alleles distribution didn’t show a significant difference between susceptible and antibiotics resistance groups. Recommendations therefore, it may not be necessary to administrate different treatment regimens for children who are infected by antibiotics resistance of H. pylori with cagA, vacA positive.
Eda Yaldirak is a 4th year medical student at University of Dokuz Eylul. She has participated in research on evaluation of the satisfaction of patients' relatives in anesthesia intensive care unit (Published in Dokuz Eylul University Magazine). She has also worked in research on ethic and quality standards about informing customers (Workshop, EMSA) and in research and workshop program about contraception methods at Dokuz Eylul University. Analyzing Helicobacter pylori is her recent and focus point.
Statement of the Problem: Helicobacter pylori cause serious health problems including gastritis, peptic ulcer disease, gastric cancer and MALT-lymphoma. Although many researches have been indicated animal originated raw foods contain H. pylori, still people continue their eating habits. Mainly they are aware of the problem but don’t realize how serious it is. Previous researches indicate that prevalence of H. pylori is very high in Turkey and it is also very high among university students (63%). The purpose of this study is to indicate the perspective of people for eating animal originated raw food.
Survey is conducted with 193 participants above age 10, and all living in İzmir. Chi-square test has been conducted to analyze relation between demographic information (age interval, sex and education level) and eating habits and information about eating uncooked red meat, egg, milk and chicken meat. Findings: There is no significant correlation between demographic information of people (sex, age interval and education level) and eating uncooked red meat, egg, milk and chicken meat. Ratio of eating foods including uncooked meat (cow and sheep) is very high, even though most of them think that it is unhealthy. This is the case also for raw egg. Ratios are better for raw chicken meat and raw milk. There is a statistically significant relation between information about eating animal originated raw foods and eating habits (except red meat). However there is no relation between education levels and awareness of health problems regarding consumption of animal originated raw foods. Conclusion: Threat of H. pylori should be announced clearly to change food consumption habits. This survey indicates that education level does not have significant relation on food consumption habits for raw red meat, milk, egg and chicken meat. A complementary education method should be sought to increase the awareness.